Tetracyclines are known to down-regulate the industry of proinflammatory cytokines such as IL-1 and TNF-alpha. They also inhibit neutrophil chemotaxis and the act of nitric oxide, reactive oxygen sort, and mold metalloproteinases (MMP). This knowledge of tetracyclines to modulate the inflammatory way substantia alba, loss the inflammatory reaction, is believed to be the rationale for its power in treating rosacea.
Tetracyclines are highly effective for papulopustular rosacea, requiring only 3-4 weeks of management for substantial change of state. Tetracycline 250-1000mg q.d., doxycycline 100-200mg q.d., and minocycline 100-200mg q.d. are most common. Use of oral tetracyclines until clinical betterment is seen, followed by a transmutation to topical antibiotics offers an alternative therapeutic regimen. There are patients for whom low-dose, long-term use of antibiotics are necessary to maintain controller of their rosacea.
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