NEW YORK (Reuters Health) Jul 17 - Azithromycin discussion of pregnant women with syphilis may not prevent congenital syphilis, according to a informing in the July supplying of Sexually Transmitted Diseases.
"Azithromycin might not be an alternative to prevent congenital syphilis," Dr. Pingyu Zhou from Shanghai Skin & STD Health facility, Republic of China told Reuters Welfare. "If azithromycin is used in treating maternal syphilis, physicians should be very cautious in masses up the mother superior and baby."
Dr. Zhou and associates treated five infants born to mothers treated (at different hospitals) for syphilis with azithromycin during pregnancy because of penicillin allergy. The infants were referred because of skin rashes.
All five infants proved to have congenital syphilis that responded without further hindrance to 14 days of intravenous or intramuscular penicillin.
The precise intellect for the bankruptcy of azithromycin to prevent congenital syphilis in these patients is alien, the researchers note, but previous investigating has shown low umbilical arterial and venous serum azithromycin levels in the term-gravid womanhood and low amniotic substance and fetal serum levels of azithromycin.
"This may partially news report for the nonachievement of azithromycin in preventing congenital syphilis," the investigators say.
"We plan to do some inquiry on macrolide drug capability in Asian nation," Dr. Zhou said. "And we had already reported that ceftriaxone might be an alternative to prevent congenital syphilis, but the samples were too body part (only 11 cases)."
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